This Patient Information leaflet summarizes the most important information about IMITREX. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about IMITREX that is written for healthcare professionals. Certain conditions can increase your risk for heart problems. Tell your doctor if you have any of these conditions, including: high blood pressure, high cholesterol, diabetes, family history of heart disease, overweight, smoker, postmenopausal women age more than 40 years men. Storage requirements: The manufacturer's product information should be consulted. cymbalta price in south africa
Do you have any chest pain, heart disease, shortness of breath, or irregular heartbeats? Franceschini R, Cataldi A, Garibaldi A, Cianciosi P, Scordamaglia A, Barreca T, Rolandi E "The effects of sumatriptan on pituitary secretion in man. This medication should be taken only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.
There was no evidence to suggest that treatment with Imitrex Tablets was associated with an increase in the severity of recurrent headaches. It helps to keep a daily diary about your headaches. Every day, simply note whether you got one, and if you did, what symptoms you had. It also helps to include information about what you had to eat or drink, what was going on that day in your life, and how you slept the night before. You should take preventive medicine, unless your headache periods last less than 2 weeks. It's so bad that most people can't sit still and will often pace during an attack.
If the migraine has not resolved by 2 hours after taking Imitrex Tablets, or returns after a transient improvement, a second dose may be administered at least 2 hours after the first dose. The maximum daily dose is 200 mg in a 24-hour period. The systematic approach described above is intended to reduce the likelihood that patients with unrecognized cardiovascular disease will be inadvertently exposed to sumatriptan. IMITREX Injection should not be given intravenously because of its potential to cause coronary vasospasm.
If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Imitrex tablets are a serotonin 5-HT 1 receptor agonist "triptan". It works by narrowing blood vessels in the brain, which helps to relieve migraines. CAD, female with surgical or physiological menopause, or male over 40 years of age unless a cardiovascular evaluation provides satisfactory clinical evidence that the patient is reasonably free of coronary artery and ischemic myocardial disease or other significant underlying cardiovascular disease. The sensitivity of cardiac diagnostic procedures to detect cardiovascular disease or predisposition to coronary artery vasospasm is modest, at best. The maximum single recommended adult dose of Imitrex Injection is 6 mg injected subcutaneously under the skin. Imitrex and certain other medicines can affect each other, causing serious side effects. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Imitrex may cause serious side effects. See “What is the most important information I should know about Imitrex? Rarely, serious and sometimes fatal heart problems eg, heart attack, irregular heartbeat have happened within a few hours of using Imitrex tablets. Contact your doctor at once if fast or irregular heartbeat; chest, throat, jaw, or neck tightness, pain, pressure, or heaviness; breaking out in a cold sweat; shortness of breath; numbness or tingling of an arm or leg; severe stomach pain, dizziness, or vomiting; or fainting occur. Discuss any questions or concerns with your doctor. Neither of these adverse events was associated with a serious clinical outcome. Take this only as needed when a occurs, as directed by your doctor. This medication should not be taken on a regular schedule. Never increase your dose of this medication or take it more often than prescribed by your doctor. Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Ottervanger JP, van Witsen TB, Valkenburg HA, Stricker BH "Postmarketing study of cardiovascular adverse reactions associated with sumatriptan.
Burning, pain, or soreness in the nose nasal spray. When you inject the dose, make sure the Pen stays in contact with your skin during the injection. It is important to hold the Pen against the skin for at least 5 seconds. GSK group of companies. 10000000124083 Rev. IMITREX Injection is administered to treat any subsequent attacks. Some of the side effects that can occur with sumatriptan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Do you have high blood pressure? Before injecting IMITREX, check with your doctor on acceptable injection sites and see the instructions inside the carton on discarding empty syringes and reloading an autoinjector device. At what time of day do the headaches happen? In assessing this information, the following additional findings should be considered. Store your medicine away from heat and light. Store sumatriptan at room temperature away from moisture, heat, and light. What happens if I miss a dose? Imitrex Injection is a prescription medicine used to treat acute migraine headaches with or without aura and acute cluster headaches in adults who have been diagnosed with migraine or cluster headaches. Imitrex tablets are to be used only by the patient for whom it is prescribed. Do not share it with other people. Some patients experience pain or tightness in the chest or throat when using IMITREX Injection. If this happens to you, then discuss it with your doctor before using any more IMITREX Injection. If the chest pain is severe or does not go away, call your doctor immediately. IMITREX sumatriptan succinate Injection is a selective 5-hydroxytryptamine 1 receptor subtype agonist. serevent
Gastrointestinal: Ischemic colitis with rectal bleeding see xerostomia. This information should not be used to decide whether or not to take Imitrex tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Imitrex tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Imitrex tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Imitrex tablets. These side effects can increase the risk of falling. Do not use more than the amount prescribed by your doctor in a 24-hour period or treat more than 4 headaches within 30 days without checking with your doctor. Overuse of drugs to treat sudden migraine attacks can lead to worsening of headache medication overuse headache or rebound headache. Therefore, do not use this medication more often or for longer than prescribed. Tell your doctor if you need to use this medication more often, if the medication is not working as well, or if you have more frequent or worse headaches. Prompt treatment allows you to get back to your normal routine and may decrease your need for other pain medications. volno.info fludrocortisone
CAD prior to receiving Imitrex Injection. If there is evidence of CAD or coronary artery vasospasm, Imitrex Injection is contraindicated. For patients with multiple cardiovascular risk factors who have a negative cardiovascular evaluation, consider administering the first dose of Imitrex Injection in a medically supervised setting and performing an electrocardiogram ECG immediately following administration of Imitrex Injection. For such patients, consider periodic cardiovascular evaluation in intermittent long-term users of Imitrex Injection. Use: For the acute treatment of migraine with or without aura. General: Chest, jaw, or neck tightness is relatively common after administration of IMITREX Injection. Chest discomfort and jaw or neck tightness have been reported following use of IMITREX Tablets and have also been reported infrequently following the administration of IMITREX sumatriptan Nasal Spray. Only rarely have these symptoms been associated with ischemic ECG changes. However, because sumatriptan may cause coronary artery vasospasm, patients who experience signs or symptoms suggestive of angina following sumatriptan should be evaluated for the presence of CAD or a predisposition to Prinzmetal variant angina before receiving additional doses of sumatriptan and should be monitored electrocardiographically if dosing is resumed and similar symptoms recur. Serious and sometimes fatal brain blood vessel problems like stroke have rarely happened with Imitrex tablets. Contact your doctor at once if you have confusion, one-sided weakness, or speech or vision changes. Do not consider Communities as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Since the injection is intended to be given subcutaneously, intramuscular or intravascular delivery should be avoided. Patients should be directed to use injection sites with an adequate skin and subcutaneous thickness to accommodate the length of the needle. See at the end of this labeling for the text of the separate leaflet provided for patients. Tmax was 12 minutes after injection range: 5 to 20 minutes. What are the ingredients in Imitrex Injection? Imitrex Nasal Spray sumatriptan Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Table 3, onset of relief began as early as 10 minutes following a 6-mg Imitrex Injection. Lower doses of Imitrex Injection may also prove effective, although the proportion of patients obtaining adequate relief was decreased and the latency to that relief is greater with lower doses. buy tegretol now
Rarely, serious and sometimes fatal heart problems eg, heart attack, irregular heartbeat have happened within a few hours of using Imitrex spray. Contact your doctor at once if fast or irregular heartbeat; chest, throat, jaw, or neck tightness, pain, pressure, or heaviness; breaking out in a cold sweat; shortness of breath; numbness or tingling of an arm or leg; severe stomach pain, dizziness, or vomiting; or fainting occur. Discuss any questions or concerns with your doctor. Check the expiration date on the Cartridge Pack. Mild or flushing may occur. These effects are usually temporary and may disappear as your body adjusts to this product. If any of these effects persist or worsen, contact your doctor or promptly. There were no statistically significant differences between the 50-mg and 100-mg dose groups in any trial. Overdose in animals has been fatal and has been heralded by convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, abnormal respiration, cyanosis, ataxia, mydriasis, salivation, and lacrimation. IMITREX STATdose Pen, 2 prefilled single-dose syringe cartridges, and 1 carrying case NDC 0173-0739-00. NOTE: These photos can be used only for identification by shape, color, and imprint. They do not depict actual or relative size. Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Do not store in the bathroom. Do not discard the auto-injector. You may use it again with refills of the prefilled syringes. However, if you are using a one-time use auto-injector, discard the auto-injector after use. If you are unsure if your auto-injector can be re-used, ask your pharmacist. Keep all medicines away from children and pets. IMITREX Injection, call your doctor immediately. Seizures have happened in people taking Imitrex who have never had seizures before. Talk with your healthcare provider about your chance of having seizures while you take Imitrex. The figure shows the probability over time of obtaining headache response no or mild pain following treatment with oral sumatriptan. The averages displayed are based on pooled data from the 3 clinical controlled trials providing evidence of efficacy. Metabolism: In vitro studies with human microsomes suggest that sumatriptan is metabolized by MAO, predominantly the A isoenzyme. Most of a radiolabeled dose of sumatriptan excreted in the urine is the major metabolite indole acetic acid IAA or the IAA glucuronide, both of which are inactive. Remember, if you answered YES to any of the above questions, then discuss it with your doctor. buy zyrtec eu
Dihydroergotamine can be effective in some people who do not get relief from triptans. Osteopaths also can use manipulation and soft-tissue techniques to the head, neck, and upper back. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Sumatriptan is a headache medicine that narrows blood vessels around the brain. Sumatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms. Push the Blue Button. The pharmacokinetics of sumatriptan in the elderly mean age: 72 years, 2 males and 4 females and in subjects with migraine mean age: 38 years, 25 males and 155 females were similar to that in healthy male subjects mean age: 30 years. This product contains salt sodium. Before using this drug, tell your doctor if you are limiting the amount of salt in your diet. Triptans narrow constrict vessels in the and relieve swelling. Triptans have other properties that may help treat symptoms. To use Imitrex spray, remove the nasal spray unit from the plastic pack. Rebound headaches were a problem in my teens. When Imitrex came out I was very impressed by how effective it was. I have been using it for about 10-12 years and I am now experiencing some problems with my migraines not easing up like they used too. Also, I have began to experience "leg migraines" with my regular migraines. They only react to the statdose injection. Injection: 4-mg and 6-mg single-dose prefilled syringe cartridges for use with the IMITREX STATdose Pen. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Because IMITREX Injection may increase blood pressure, it should not be given to patients with uncontrolled hypertension. The Pen will only work when the Safety Catch is released. Ask your healthcare provider if you should take your first dose in a medical setting. Six of these 8 patients had ECG changes consistent with transient ischemia, but without accompanying clinical symptoms or signs. Of these 8 patients, 4 had either findings suggestive of CAD or risk factors predictive of CAD prior to study enrollment. Treatment for these health problems also may help you have fewer headaches. Heart Rate: Transient increases in blood pressure observed in some patients in clinical studies carried out during sumatriptan's development as a treatment for migraine were not accompanied by any clinically significant changes in heart rate. The plot was constructed with data from patients who either experienced relief or did not require request rescue medication within a period of 2 hours following treatment. As a consequence, the data in the plot are derived from only a subset of the 258 headaches treated rescue medication was required in 52 of the 127 placebo-treated headaches and 18 of the 131 headaches treated with Imitrex Injection. You may begin to sweat a lot, or light may bother you. Your healthcare provider may change your dose. Clinical trials of Imitrex Injection did not include sufficient numbers of patients 65 years of age and older to determine whether they respond differently from younger patients. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy. What should I discuss with my healthcare provider before using sumatriptan? Have you ever had to stop taking this or any other medicine because of an allergy or other problems? IMITREX Nasal Spray sumatriptan nasal spray is generally well tolerated. Across all doses, most adverse reactions were mild and transient and did not lead to long-lasting effects. The incidence of adverse events in controlled clinical trials was not affected by gender, weight, or age of the patients; use of prophylactic medications; or presence of aura. There were insufficient data to assess the impact of race on the incidence of adverse events. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use and wear protective clothing when outdoors. Dogs receiving oral sumatriptan developed corneal opacities and defects in the corneal epithelium. mail order generic prozac shopping
Product Information. Zecuity SUMAtriptan. IMITREX STATdose System NDC 0173-0739-02. For adults, the usual dose is a single injection given just below the skin. Do not flush down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Before treating headaches in patients not previously diagnosed with migraine or cluster headache or in patients who present with atypical symptoms, exclude other potentially serious neurological conditions. Imitrex Injection is contraindicated in patients with a history of stroke or TIA. Keep all regular medical and laboratory appointments. Table 1 lists adverse reactions that occurred in 2 US placebo-controlled clinical trials in migraine patients Studies 2 and 3 following either a single 6-mg dose of Imitrex Injection or placebo. Drowsiness may occur during a migraine or during its treatment with this drug. Do not drive or operate machinery until you know how this drug affects you. Burns and scars have been reported on the skin where the transdermal iontophoretic transdermal system has been worn. These reports describe severe redness, pain, skin discoloration, blistering, and cracked skin. On June 13, 2016, the manufacturer of the patch suspended sales and distribution of the patch to investigate the cause of these reports. Button until you have pressed the Pen against your skin to give a dose. Cluster headaches are more common in people who smoke or are heavy drinkers. During a cluster period, you'll be more sensitive to alcohol and nicotine -- just a bit of alcohol can trigger a headache. But drinking won't trigger one during headache-free periods. There was no evidence of an increase in tumors in either species related to sumatriptan administration. If you feel unwell in any other way or have any symptoms that you do not understand, you should contact your doctor immediately. Preferred administration sites are the subcutaneous tissues of the lateral aspect of the thighs or the subcutaneous tissues overlying the deltoid muscles. costco pharmacy cefdinir price
Product Information. Imitrex nasal spray sumatriptan. MAO-A inhibitors reduce sumatriptan clearance, significantly increasing systemic exposure. Therefore, the use of sumatriptan in patients receiving MAO-A inhibitors is not ordinarily recommended. If you are taking a liquid product, use a medication-measuring device to carefully measure the dose. Do not use a household spoon. Some liquid products need to be shaken before each dose. Some products that contain need to be placed under the and held there before swallowing. Follow label directions carefully to get the most benefit. Once the first nosepiece has been administered, press the clear tab and remove the first nosepiece; check to see if the medication is gone from the capsule; discard used nosepiece and repeat with a second nosepiece in the second nostril; it is normal to see a thin white residue after use. You can buy some over the counter. But stronger NSAIDs need a prescription. Inform patients that the injection is intended to be given subcutaneously and intramuscular or intravascular delivery should be avoided. Instruct patients to use injection sites with an adequate skin and subcutaneous thickness to accommodate the length of the needle. HT 1 agonists. Since visual disorders may be part of a migraine attack, a causal relationship between these events and the use of 5-HT 1 agonists have not been clearly established. This should not be taken if you have certain medical conditions. IMITREX STATdose System, 6 mg, containing 1 IMITREX STATdose Pen, 2 prefilled single-dose syringe cartridges, and 1 carrying case NDC 0173-0479-00. Some medical conditions may interact with Imitrex spray. The name of your medicine is IMITREX sumatriptan succinate Injection. It can be obtained only by prescription from your doctor. The decision to use IMITREX Injection is one that you and your doctor should make jointly, taking into account your individual preferences and medical circumstances. If you have risk factors for heart disease such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease, or you are postmenopausal or a male over 40 you should tell your doctor, who should evaluate you for heart disease in order to determine if IMITREX is appropriate for you. Although the vast majority of those who have taken IMITREX have not experienced any significant side effects, some individuals have experienced serious heart problems and, rarely, considering the extensive use of IMITREX worldwide, deaths have been reported. In all but a few instances, however, serious problems occurred in people with known heart diseases and it was not clear whether IMITREX was a contributory factor in these deaths. Avoid for at least 12 hours after using sumatriptan. Consult your doctor before -feeding. Pedialyte and drinking it. I also recommend asking your doctor about the Compazine. You should also understand WHY your body is reacting with the diarrhea. There is obviously a connection between our digestive systems and the intense headaches. I just worry that I've opened up Pandora's box in my body and will now have to deal with migraine headaches in the future. sinemet
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This drug may rarely cause serious possibly fatal disease. Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health and perhaps your life at risk. Do not take more than 12 mg in a 24-hour period. What should I avoid while taking Imitrex? raloxifene purchase now europe
What is the most important information I should know about IMITREX? Single doses of 5, 10, or 20 mg of Imitrex Nasal Spray administered into 1 nostril were effective for the acute treatment of migraine in adults. Use calendars and clocks. Sumatriptan may also be used for purposes not listed in this medication guide. Safety and efficacy have not been established in patients younger than 18 years.
Product Information. Imitrex injection sumatriptan. IMITREX may cause serious side effects. Check with your pharmacist about how to dispose of unused medicine. Cluster Headache: The efficacy of IMITREX Injection in the acute treatment of cluster headache was demonstrated in 2 randomized, double-blind, placebo-controlled, 2-period crossover trials. Patients age 21 to 65 were enrolled and were instructed to treat a moderate to very severe headache within 10 minutes of onset. Headache relief was defined as a reduction in headache severity to mild or no pain. In both trials, the proportion of individuals gaining relief at 10 or 15 minutes was significantly greater among patients receiving 6 mg of IMITREX Injection compared to those who received placebo see Table 3. One study evaluated a 12-mg dose; there was no statistically significant difference in outcome between patients randomized to the 6- and 12-mg doses.
They also simutaniously hurt the eye area. If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Discuss the risks and benefits with your doctor.